205678-31-5

205678-31-5 structure

Name: SB273005
Chemical Name: HG7MY8V9AA
CAS Number: 205678-31-5
Molecular Formula: C₂₂H₂₄F₃N₃O₄
Molecular Weight: 451.44
Catalog: Biochemical Inhibitor Cytoskeletal Signaling Integrin inhibitor
Create Date: 2018-06-05 13:25:19
Modify Date: 2024-01-10 01:39:09
SB-273005 is a potent nonpeptide and orally active integrin antagonist with Kis of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively[1].

Name	HG7MY8V9AA
Synonyms	[(4S)-8-{2-[6-(Methylamino)-2-pyridinyl]ethoxy}-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-yl]acetic acid 1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-8-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-, (4S)- [(4S)-8-{2-[6-(methylamino)pyridin-2-yl]ethoxy}-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-yl]acetic acid HG7MY8V9AA SB273005

Description	SB-273005 is a potent nonpeptide and orally active integrin antagonist with Kis of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Integrin
References	[1]. Badger AM, et al. Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis. Arthritis Rheum. 2001 Jan;44(1):128-37.