1056024-94-2

1056024-94-2 structure

Name: N3-PEG3-CH2CH2COOH
Chemical Name: 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid
CAS Number: 1056024-94-2
Molecular Formula: C₉H₁₇N₃O₅
Molecular Weight: 247.248
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-06-29 19:07:13
Modify Date: 2024-01-04 22:13:24
N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Name	3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid
Synonyms	Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]- 3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid

Description	N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.