1079043-55-2

1079043-55-2 structure

Name: AVP-786
Chemical Name: Deudextromethorphan
CAS Number: 1079043-55-2
Molecular Formula: C₁₈H₁₉D₆NO
Molecular Weight: 277.434
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-10-17 14:21:56
Modify Date: 2025-08-23 23:12:21
Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].

Name	Deudextromethorphan
Synonyms	Morphinan, 17-(methyl-d3)-3-(methyl-d3-oxy)-, (9α,13α,14α)- UNII:427476LZFT 3-[(2H3)methoxy]-17-[(2H3)methyl]-ent-morphinan Deudextromethorphan 427476LZFT CTP-786 DEXTROMETHORPHAN D6 (9α,13α,14α)-17-(2H3)Methyl-3-[(2H3)methyloxy]morphinan 10288 d6-DM

Description	Deudextromethorphan (AVP-786) is a deuterated form of dextromethorphan/quinidine (AVP-923, Nuedexta). Deudextromethorphan, a glutamate-targeting agent, is an orally active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan can be used for the research of Pseudo-Bulbar Affect, traumatic brain injury, behavioral disinhibition and agitation in AD[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
References	[1]. Khoury R, et al. AVP-786 as a promising treatment option for Alzheimer's Disease including agitation. Expert Opin Pharmacother. 2021 May;22(7):783-795. [2]. Garay RP, et al. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert Opin Investig Drugs. 2017 Jan;26(1):121-132. [3]. Hecking J, et al. Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders. Chronic Stress (Thousand Oaks). 2021 Jun 2;5:24705470211020446.