1467093-03-3

1467093-03-3 structure

Name: Adavivint
Chemical Name: 10389
CAS Number: 1467093-03-3
Molecular Formula: C₂₉H₂₄FN₇O
Molecular Weight: 505.546
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2018-07-01 02:14:57
Modify Date: 2024-01-08 19:16:35
Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.

Name	10389
Synonyms	Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl- 42EK42WHI5 N-(5-{3-[7-(3-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}-3-pyridinyl)-3-methylbutanamide Adavivint

Description	Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Inflammation/Immunology
Target	EC50: 19.5 nM (Wnt, SW480 cell)[1]
In Vitro	Adavivint (SM04690) is a potent and selective inhibitor of Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells, and shows no effect on SV40 luciferase reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro[1].
In Vivo	Adavivint (0.3 μg) enhances cartilage repair and protection in the rat acute cruciate ligament tear and partial medial meniscectomy osteoarthritis (ACLT + pMMx OA) model[1].
References	[1]. Deshmukh V, et al. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2018 Jan;26(1):18-27.