120944-03-8

120944-03-8 structure

Name: HNMPA-(AM)3
Chemical Name: hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
CAS Number: 120944-03-8
Molecular Formula: C₂₀H₂₃O₁₀P
Molecular Weight: 454.364
Create Date: 2018-06-29 20:40:48
Modify Date: 2024-03-02 16:35:02
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis[1].

Name	hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
Synonyms	Phosphonic acid, P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-, bis[(acetyloxy)methyl] ester hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester 3-(Acetoxymethoxy)-4-(2-naphthyl)-3-oxido-8-oxo-2,5,7-trioxa-3λ5-phosphanon-1-yl acetate

Description	HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor
References	[1]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca²⁺/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101.