124649-78-1

124649-78-1 structure

Name: (-)-Dihydroguaiaretic acid
Chemical Name: G8DW2Y2JBT
CAS Number: 124649-78-1
Molecular Formula: C₂₀H₂₆O₄
Molecular Weight: 330.418
Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
Create Date: 2018-06-25 06:13:30
Modify Date: 2024-01-14 10:10:09
(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2].

Name	G8DW2Y2JBT
Synonyms	G8DW2Y2JBT 4,4'-[(2R,3R)-2,3-Dimethyl-1,4-butanediyl]bis(2-methoxyphenol) Phenol, 4,4'-[(2R,3R)-2,3-dimethyl-1,4-butanediyl]bis[2-methoxy- 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol) (-)-dihydroguaiaretic acid

Description	(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. [2]. Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392.