261956-22-3
261956-22-3 structure
- Name: RO 28-2653
- Chemical Name: 5-(4-Biphenylyl)-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione
- CAS Number: 261956-22-3
- Molecular Formula: C26H23N5O5
- Molecular Weight: 485.491
- Create Date: 2018-06-23 00:36:54
- Modify Date: 2025-08-29 11:42:25
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RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
| Name | 5-(4-Biphenylyl)-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione |
|---|---|
| Synonyms |
5-(4-Biphenylyl)-5-[4-(4-nitrophenyl)-1-piperazinyl]-2,4,6(1H,3H,5H)-pyrimidinetrione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[1,1'-biphenyl]-4-yl-5-[4-(4-nitrophenyl)-1-piperazinyl]- RO 28-2653 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H23N5O5 |
| Molecular Weight | 485.491 |
| Exact Mass | 485.169922 |
| LogP | 5.28 |
| Index of Refraction | 1.649 |
| Storage condition | 2-8°C |