876296-47-8

876296-47-8 structure

Name: Revefenacin
Chemical Name: SELEPRESSIN
CAS Number: 876296-47-8
Molecular Formula: C₄₆H₇₃N₁₃O₁₁S₂
Molecular Weight: 1048.282
Catalog: Signaling Pathways GPCR/G Protein Vasopressin Receptor
Create Date: 2018-07-21 11:58:31
Modify Date: 2025-08-26 19:07:03
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].

Name	SELEPRESSIN
Synonyms	Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-6-oxo-L-lysyl-L-asparaginyl-L-cysteinyl-L-prolyl-N5-(1-methylethyl)-L-ornithyl-, cyclic (1→6)-disulfide 8P2T76M0SJ [2-L-phenylalanine,3-L-isoleucine,4-(6-oxo-L-lysine),8-[5-N-(1-methylethyl)-L-ornithine]]human vasopressin 9418 1-({(4R,7S,10S,13S,16S,19R)-19-Amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-2-butanyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-pro ;lyl-N5-isopropyl-L-ornithylglycinamide Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloe ;icos-4-yl]carbonyl]-L-prolyl-N5-(1-methylethyl)-L-ornithyl- SELEPRESSIN FE 202158

Description	Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
In Vitro	Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3]. Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3]. Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3]. Western Blot Analysis[2] Cell Line: HLMVECs Concentration: 1, 10, 100, 1000 nM Incubation Time: 24 h, 48 h Result: Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.
In Vivo	Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4]. Animal Model: LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Dosage: 1 μg/kg/min Administration: Left jugular vein infusion for 12 min Result: Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.