Revefenacin
Modify Date: 2024-01-09 18:02:09
Revefenacin structure
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Common Name | Revefenacin | ||
|---|---|---|---|---|
| CAS Number | 876296-47-8 | Molecular Weight | 1048.282 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 1512.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C46H73N13O11S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 868.3±34.3 °C | |
Use of RevefenacinSelepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4]. |
| Name | SELEPRESSIN |
|---|---|
| Synonym | More Synonyms |
| Description | Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4]. |
|---|---|
| Related Catalog | |
| In Vitro | Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3]. Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3]. Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3]. Western Blot Analysis[2] Cell Line: HLMVECs Concentration: 1, 10, 100, 1000 nM Incubation Time: 24 h, 48 h Result: Induced p53 expression levels, but only after treatment of 48 hours at 100 nM. |
| In Vivo | Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4]. Animal Model: LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. Dosage: 1 μg/kg/min Administration: Left jugular vein infusion for 12 min Result: Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 1512.1±65.0 °C at 760 mmHg |
| Molecular Formula | C46H73N13O11S2 |
| Molecular Weight | 1048.282 |
| Flash Point | 868.3±34.3 °C |
| Exact Mass | 1047.499390 |
| LogP | -3.83 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.545 |
| Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-6-oxo-L-lysyl-L-asparaginyl-L-cysteinyl-L-prolyl-N5-(1-methylethyl)-L-ornithyl-, cyclic (1→6)-disulfide |
| 8P2T76M0SJ |
| [2-L-phenylalanine,3-L-isoleucine,4-(6-oxo-L-lysine),8-[5-N-(1-methylethyl)-L-ornithine]]human vasopressin |
| 9418 |
| 1-({(4R,7S,10S,13S,16S,19R)-19-Amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-16-benzyl-13-[(2S)-2-butanyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-pro ;lyl-N5-isopropyl-L-ornithylglycinamide |
| Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-amino-4-oxobutyl)-7-(2-amino-2-oxoethyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloe ;icos-4-yl]carbonyl]-L-prolyl-N5-(1-methylethyl)-L-ornithyl- |
| SELEPRESSIN |
| FE 202158 |