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112408-67-0

112408-67-0 structure
112408-67-0 structure
  • Name: 3-Deoxysappanchalcone
  • Chemical Name: LHE9JFQ1U8
  • CAS Number: 112408-67-0
  • Molecular Formula: C16H14O4
  • Molecular Weight: 270.280
  • Catalog: Signaling Pathways Anti-infection Influenza Virus
  • Create Date: 2018-07-11 15:46:28
  • Modify Date: 2024-01-23 03:05:41
  • 3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2].

Name LHE9JFQ1U8
Synonyms 4,4'-dihydroxy-2'-methoxychalcone
2-Propen-1-one, 1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
MFCD00800700
LHE9JFQ1U8
(2E)-1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
(2E)-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Description 3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2].
Related Catalog
Target

IC50: 1.06 μM (H3N2)[2]

References

[1]. Kim JH, et al. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6.

[2]. Liu AL, et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Med. 2009 Mar;75(4):337-9.

Density 1.3±0.1 g/cm3
Boiling Point 527.1±50.0 °C at 760 mmHg
Melting Point 210-212 °C
Molecular Formula C16H14O4
Molecular Weight 270.280
Flash Point 200.5±23.6 °C
Exact Mass 270.089203
LogP 2.96
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.658
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