3-Deoxysappanchalcone

Modify Date: 2024-01-23 03:05:41

3-Deoxysappanchalcone structure	Common Name	3-Deoxysappanchalcone
	CAS Number	112408-67-0	Molecular Weight	270.280
	Density	1.3±0.1 g/cm3	Boiling Point	527.1±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₄	Melting Point	210-212 °C
	MSDS	N/A	Flash Point	200.5±23.6 °C

Use of 3-Deoxysappanchalcone

3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2].

Name	LHE9JFQ1U8
Synonym	More Synonyms

Description	3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 1.06 μM (H3N2)[2]
References	[1]. Kim JH, et al. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6. [2]. Liu AL, et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Med. 2009 Mar;75(4):337-9.

Density	1.3±0.1 g/cm3
Boiling Point	527.1±50.0 °C at 760 mmHg
Melting Point	210-212 °C
Molecular Formula	C₁₆H₁₄O₄
Molecular Weight	270.280
Flash Point	200.5±23.6 °C
Exact Mass	270.089203
LogP	2.96
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.658