1216745-79-7

1216745-79-7 structure

Name: Mefenamic acid D4
Chemical Name: 2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
CAS Number: 1216745-79-7
Molecular Formula: C₁₅H₁₁D₄NO₂
Molecular Weight: 245.310
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-08 04:13:44
Modify Date: 2024-01-10 11:10:17
Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

Name	2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
Synonyms	2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid Benzoic-2,3,4,5-d4 acid, 6-[(2,3-dimethylphenyl)amino]-

Description	Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	hCOX-1:40 nM (IC50) hCOX-2:3 nM (IC50)
References	[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84. [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.