CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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WM3407000
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CHEMICAL NAME :
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Succinamic acid, 3-amino-N-(alpha-carboxyphenethyl)-, N-methyl ester, stereoisomer
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CAS REGISTRY NUMBER :
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22839-47-0
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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16
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MOLECULAR FORMULA :
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C14-H18-N2-O5
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MOLECULAR WEIGHT :
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294.34
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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3710 ug/kg
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TOXIC EFFECTS :
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Skin and Appendages - dermatitis, allergic (after systemic exposure)
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REFERENCE :
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AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 104,207,1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),37,1996
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),37,1996
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),37,1996
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),37,1996 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1456 gm/kg/2Y-C
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in calcium
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REFERENCE :
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TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 21,91,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1012 gm/kg/13W-C
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay) Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 3(5-6),341,1980
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4530 ug/m3/24H/6W-C
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TOXIC EFFECTS :
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Liver - other changes Endocrine - other changes Nutritional and Gross Metabolic - other changes
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REFERENCE :
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TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),37,1996
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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19500 mg/kg/30D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes
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REFERENCE :
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FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,565,1987 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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275 gm/kg
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SEX/DURATION :
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male 2 week(s) pre-mating female 2 week(s) pre-mating - 16 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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REFERENCE :
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NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY. Volume(issue)/page/year: 1,79,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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106 gm/kg
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SEX/DURATION :
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lactating female 12 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 3(5-6),375,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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449 gm/kg
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SEX/DURATION :
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male 2 week(s) pre-mating female 2 week(s) pre-mating - 21 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
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REFERENCE :
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NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY. Volume(issue)/page/year: 1,79,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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4 gm/kg
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SEX/DURATION :
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female 15-18 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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REFERENCE :
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RCPBDC Research Communications in Psychology, Psychiatry and Behavior. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1976- Volume(issue)/page/year: 9,385,1985
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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32500 mg/kg
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SEX/DURATION :
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female 1-65 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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REFERENCE :
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NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 11,413,1989
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