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56-84-8

56-84-8 structure
56-84-8 structure
Name L-aspartic acid
Synonyms Aspaginic acid
asparagic acid
ASPTIC(L-)
Aspatic acid (D) Solution, 100ppm
L-Asptic Acid, Animal-Free
L-AspticAcid
L-Asptic Acid-1,C2
L-Asp-OH
(2R)-2-aminobutanedioic acid
H-Asp-OH
ASPTIC ACID
(S)-(+)-Aminosuccinic acid (S)-Aminobutanedioic acid (S)-Aminosuccinic Acid H-Asp-OH L-Aspaginic Acid L(+)-Asptic acid
L-ASPTIC ACID, PH EUR
L-Asparticacid
L-ASPTIC ACID FREE ACID CELL CULTURETE STED
aspaginicacid
(S)-(+)-Aminosuccinic aci
(R)-(−)-Aminosuccinic acid
L-ASPTIC ACID, BIOXTRA, >= (HPL
aspartic acid D-form
L-ASPTIC ACID SIGMAULTRA
L-AspticAcidForBiochemistry-(S)-2-AminosuccinicAcid)
Aspatic acid (D)
L-Asptic acid, (Titration: anhydrous basis)
ASPTIC ACID, L-(P)
1-amino-1,2-carboxyethane
L-Asplic add
L-ASPTIC ACID, ( EE/GLC)
L-ASPTIC ACID MIN
Aspatofort
aspagicacid
(S)-Aminosuccinic Acid L-Aspaginic Acid H-Asp-OH
hydrogen D-aspartate
Aspagic acid
L-Asptic acid (non-medicinal)
L-Asptic Acid monocalcium
alpha-Aminosuccinic acid
L-Asptic acid,(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid
Acide (2R)-2-aminosuccinique
L-ASPTIC ACID FREE ACID
EINECS 200-291-6
L-Asptic Acid,(S)-Aminosuccinic Acid
L-Aminobutanedioicacid
δ-aspartic acid
(s)-butanedioicaci
QVYZ1VQ &&D or R Form
(-)-Aspartic acid
(2R)-2-Aminosuccinic acid
MFCD00002616
L-asptic acid AJI92
Butanedioic acid, amino-, (S)
L-ASPTIC ACIDRESECH ADE
L-Asptic acid, Low metals content
(S)-(+)-ASPTIC ACID
aspaginsaeure
L-AspticAcidForBiochemistry
D-Aspartic acid
H-D-Asp-OH
aspacemic acid
L-Asptic Acid FCC
d-Asp
Aspatic acid Solution (D)
L-Asptic Joyce
L-Asptic acid,(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid, Acidum aspticum
L-Asptic acid, extra , Ph Eur, BP
L-ASPTIC ACID, ADE, >=98
aspaginsaure
ASPTIC ACID, L
Dl-AspticAcidPure
Erlotinib-d7 HCl
L-Asptic acid (H-Asp-OH)
D-(-)-Aspartic acid
l-aminosuccinic acid, h-asp-oh
L(+)-Asptic acid, R
Description L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
Related Catalog
Target

Human Endogenous Metabolite

In Vivo L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].
References

[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.
Density 1.5±0.1 g/cm3
Boiling Point 264.1±30.0 °C at 760 mmHg
Melting Point >300 °C (dec.)(lit.)
Molecular Formula C4H7NO4
Molecular Weight 133.103
Flash Point 113.5±24.6 °C
Exact Mass 133.037506
PSA 100.62000
LogP -0.67
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.531
Water Solubility 5 g/L (25 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI9098500
CHEMICAL NAME :
Aspartic acid, L-
CAS REGISTRY NUMBER :
56-84-8
BEILSTEIN REFERENCE NO. :
1723530
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C4-H7-N-O4
MOLECULAR WEIGHT :
133.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25079 mg/kg/7D-C
TOXIC EFFECTS :
Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;Xn: Harmful;
Risk Phrases R36
Safety Phrases S26-S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CI9098500
HS Code 29224995
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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