1770789-37-1

1770789-37-1 structure

Name: Olinone
Chemical Name: N-[4-(1-Oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide
CAS Number: 1770789-37-1
Molecular Formula: C₁₇H₂₁N₃O₂
Molecular Weight: 299.37
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2018-06-08 21:23:49
Modify Date: 2024-03-02 22:35:16
Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].

Name	N-[4-(1-Oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide
Synonyms	N-[4-(1-Oxo-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)butyl]acetamide Acetamide, N-[4-(1,2,3,4-tetrahydro-1-oxo-5H-pyrido[4,3-b]indol-5-yl)butyl]- MFCD28976195

Description	Olinone is a selective BRD4 BrD1 inhibitor[1]. Olinone accelerates the progression of mouse primary oligodendrocyte progenitors toward differentiation[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
References	[1]. Rodríguez Y, et al. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins. 2020 Mar;88(3):414-430. [2]. Gacias M, et al. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854.

Hazard Codes	T+