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1343476-41-4

1343476-41-4 structure
1343476-41-4 structure
  • Name: Acid-C2-PEG4-C2-NHS ester
  • Chemical Name: 19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
  • CAS Number: 1343476-41-4
  • Molecular Formula: C18H29NO11
  • Molecular Weight: 435.423
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-23 11:16:58
  • Modify Date: 2024-04-05 21:21:41
  • Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
Synonyms 19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
4,7,10,13,16-Pentaoxanonadecan-1-oic acid, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-
Description Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.3±0.1 g/cm3
Boiling Point 574.8±60.0 °C at 760 mmHg
Molecular Formula C18H29NO11
Molecular Weight 435.423
Flash Point 301.5±32.9 °C
Exact Mass 435.174072
LogP -3.42
Vapour Pressure 0.0±3.4 mmHg at 25°C
Index of Refraction 1.509
Hazard Codes Xi