154822-57-8
154822-57-8 structure
- Name: Cimiside E
- Chemical Name: (1S,2R,3S,4R,7R,9S,12R,14S,17R,18R,19R,21R,22S)-2-Hydroxy-22-isopropenyl-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-9-yl β-D-xylopyranoside
- CAS Number: 154822-57-8
- Molecular Formula: C35H54O8
- Molecular Weight: 602.799
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2018-06-15 03:55:52
- Modify Date: 2024-01-15 06:48:13
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Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the Caspase cascade for both the extrinsic and intrinsic pathways[1][2].
| Name | (1S,2R,3S,4R,7R,9S,12R,14S,17R,18R,19R,21R,22S)-2-Hydroxy-22-isopropenyl-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-9-yl β-D-xylopyranoside |
|---|---|
| Synonyms |
β-D-Xylopyranoside, (2S,4aR,5aS,7aR,7bR,8R,10R,11S,12aS,13R,13aS,13bR,15aR)-heptadecahydro-13-hydroxy-1,1,7a,8,13a-pentamethyl-11-(1-methylethenyl)-10,12a-epoxy-2H,5H-cyclopropa[1',8'a]naphth[2',1' :4,5]indeno[2,1-b]oxepin-2-yl
(1S,2R,3S,4R,7R,9S,12R,14S,17R,18R,19R,21R,22S)-2-Hydroxy-22-isopropenyl-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-9-yl β-D-xylopyranosi 
de |
| Description | Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the Caspase cascade for both the extrinsic and intrinsic pathways[1][2]. |
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| Related Catalog | |
| Target |
Caspase 3 |
| In Vitro | Cimiside E (30-90 μM; 24 h) 阻滞细胞周期，诱导 ASG 细胞凋亡[1]。 Cimiside E (30-90 μM; 12-48 h) 对 AGS 细胞有较强的细胞毒性，并表现出抗增殖活性[1]。 Cimiside E (15-60 μM; 6-24 h) 诱导 ASG细胞中 DNA 片段化，(30-60 μM; 1-6 h) 并在 3 h 时激活 FasL 的表达，在 1 h 激活 Fas[1]。 Cimiside E (30-90 μM; 3-24 h) 介导 caspase 级联，增加 Bax/Bcl-2 比值，降低突变型 p53 和 procaspase 3 蛋白水平[1]。 Western Blot Analysis[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 3 h, 6 h, 12 h, and 24 h Result: Increased the ratio of Bax/Bcl-2 expression from 60 μM. Decreased mutant type (mt) p53 levle from 12 h at 30 µM. Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM. Cell Proliferation Assay[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 12 h, 24 h, and 48 h Result: Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment. Cell Cycle Analysis[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 3 h, 6 h, and 24 h Result: Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM). |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 723.8±60.0 °C at 760 mmHg |
| Molecular Formula | C35H54O8 |
| Molecular Weight | 602.799 |
| Flash Point | 391.6±32.9 °C |
| Exact Mass | 602.381897 |
| LogP | 6.81 |
| Vapour Pressure | 0.0±5.3 mmHg at 25°C |
| Index of Refraction | 1.602 |