Name | 10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone |
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Synonyms |
9(10H)-Anthracenone, 10-[(3-hydroxy-4-methoxyphenyl)methylene]-
10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone 10-(3-hydroxy-4-methoxybenzylidene)anthracen-9(10H)-one |
Description | Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1]. |
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Related Catalog | |
In Vitro | Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner[1]. Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM[1]. Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM[1]. Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 524.7±50.0 °C at 760 mmHg |
Molecular Formula | C22H16O3 |
Molecular Weight | 328.361 |
Flash Point | 188.8±23.6 °C |
Exact Mass | 328.109955 |
LogP | 3.80 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.700 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |