1006335-39-2

1006335-39-2 structure

Name: ISPA-28
Chemical Name: N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide
CAS Number: 1006335-39-2
Molecular Formula: C₂₁H₂₄N₆O₃
Molecular Weight: 408.454
Catalog: Research Areas Infection
Create Date: 2018-06-04 17:45:27
Modify Date: 2025-08-25 17:08:17
ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2].

Name	N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide
Synonyms	5-Isoxazolecarboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro- N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide MFCD08106635

Description	ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	ISPA-28 is only effective as an inhibitor of Dd2 channels (K0.5 values of 56 nM and 43 μM for Dd2 and HB3 channels, respectively)[2].
References	[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes. [2]. Wang Nguitragool, et al. Proteolysis at a Specific Extracellular Residue Implicates Integral Membrane CLAG3 in Malaria Parasite Nutrient Channels.

RIDADR	NONH for all modes of transport