ISPA-28
Modify Date: 2025-08-25 17:08:17
ISPA-28 structure
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Common Name | ISPA-28 | ||
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| CAS Number | 1006335-39-2 | Molecular Weight | 408.454 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H24N6O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ISPA-28ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2]. |
| Name | N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide |
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| Synonym | More Synonyms |
| Description | ISPA-28 is a specific plasmodial surface anion channel (PSAC) antagonist. ISPA-28 binds directly and reversibly to CLAG3[1][2]. |
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| Related Catalog | |
| In Vitro | ISPA-28 is only effective as an inhibitor of Dd2 channels (K0.5 values of 56 nM and 43 μM for Dd2 and HB3 channels, respectively)[2]. |
| References |
[1]. Sanjay A Desai, et al. Ion and Nutrient Uptake by Malaria Parasite-Infected Erythrocytes. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H24N6O3 |
| Molecular Weight | 408.454 |
| Exact Mass | 408.190979 |
| LogP | 0.18 |
| Index of Refraction | 1.672 |
| InChIKey | YMLINDVVJXDIRW-UHFFFAOYSA-N |
| SMILES | CCn1cc(C2=NOC(C(=O)Nc3c(C)n(C)n(-c4ccccc4)c3=O)C2)c(C)n1 |
| RIDADR | NONH for all modes of transport |
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An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.
J. Biol. Chem. 288(27) , 19429-40, (2013) Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level chang... |
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Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.
Future Microbiol. 5(1) , 81-97, (2010) Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been kn... |
| 5-Isoxazolecarboxamide, N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro- |
| N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide |
| MFCD08106635 |