153322-06-6

153322-06-6 structure

Name: Lanicemine dihydrochloride
Chemical Name: 59E712CNQR
CAS Number: 153322-06-6
Molecular Formula: C₁₃H₁₆Cl₂N₂
Molecular Weight: 271.185
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-07-13 06:08:38
Modify Date: 2024-01-03 19:41:28
Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

Name	59E712CNQR
Synonyms	(1S)-1-Phenyl-2-(2-pyridinyl)ethanamine dihydrochloride LANICEMINE DIHYDROCHLORIDE 59E712CNQR 2-Pyridineethanamine, α-phenyl-, (αS)-, hydrochloride (1:2) MFCD00936874

Description	Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA receptor[1]
In Vivo	Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
References	[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.