66069-55-4
66069-55-4 structure
- Name: Tigloylgomisin H
- Chemical Name: 563Q173U7G
- CAS Number: 66069-55-4
- Molecular Formula: C28H36O8
- Molecular Weight: 500.581
- Catalog: Natural product Lignans
- Create Date: 2018-06-09 08:38:56
- Modify Date: 2024-01-12 12:16:13
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Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].
| Name | 563Q173U7G |
|---|---|
| Synonyms |
UNII:563Q173U7G
TIGLOYLGOMISIN H 563Q173U7G (6S,7S)-7-Hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-1-yl (2E)-2-methyl-2-butenoate 2-Butenoic acid, 2-methyl-, (6S,7S)-5,6,7,8-tetrahydro-7-hydroxy-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-1-yl ester, (2E)- |
| Description | Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1]. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 656.3±55.0 °C at 760 mmHg |
| Molecular Formula | C28H36O8 |
| Molecular Weight | 500.581 |
| Flash Point | 212.3±25.0 °C |
| Exact Mass | 500.241028 |
| LogP | 4.92 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.539 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
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