881188-51-8

881188-51-8 structure

Name: Foxy 5 TFA
Chemical Name: FOXY-5
CAS Number: 881188-51-8
Molecular Formula: C₂₆H₄₂N₆O₁₂S₂
Molecular Weight: 694.775
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2018-07-18 10:44:58
Modify Date: 2025-08-25 20:10:02
Foxy-5 is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 is a WNT5A agonist and effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2].

Name	FOXY-5
Synonyms	FOXY-5 N-Formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-L-leucine CBZ9UL0ARB L-Leucine, N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-

Description	Foxy-5 is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 is a WNT5A agonist and effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	WNT5A[1]
In Vivo	Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model[1]. Foxy-5 reduces the number of colonic cancer stem cells in a xenograft mouse model of human colonic cancer[2].
References	[1]. Canesin G, et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One. 2017 Sep 8;12(9):e0184418. [2]. Osman J, et al. The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic Cancer. Anticancer Res. 2019 Apr;39(4):1719-1728.