141256-04-4
141256-04-4 structure
- Name: QS-21
- Chemical Name: 61H83WZX3U
- CAS Number: 141256-04-4
- Molecular Formula: C92H148O46
- Molecular Weight: 1990.13
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2018-06-23 04:25:54
- Modify Date: 2025-08-27 11:02:30
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QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3].
| Name | 61H83WZX3U |
|---|---|
| Synonyms | 61H83WZX3U |
| Description | QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
NLRP3 inflammasome |
| In Vivo | Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3]. |
| References |
| Molecular Formula | C92H148O46 |
|---|---|
| Molecular Weight | 1990.13 |
| Hazard Codes | Xi |
|---|