1310540-32-9
1310540-32-9 structure
- Name: MPC-0767
- Chemical Name: MPC-0767
- CAS Number: 1310540-32-9
- Molecular Formula: C26H36BrN7O9S2
- Molecular Weight: 734.64
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2018-06-13 04:41:39
- Modify Date: 2024-01-29 23:31:02
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MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability[1].
| Name | MPC-0767 |
|---|
| Description | MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability[1]. |
|---|---|
| Related Catalog | |
| Target |
HSP90 |
| In Vivo | MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the Tmax, Cmax, AUC and F% are 1 (h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1]. MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1]. MPC-0767 is well tolerated when administered at 252 mg/kg po (equivalent to 200 mg/kg dose of MPC-3100)[1]. |
| References |
| Molecular Formula | C26H36BrN7O9S2 |
|---|---|
| Molecular Weight | 734.64 |