MPC-0767
Modify Date: 2025-09-18 10:16:38
MPC-0767 structure
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Common Name | MPC-0767 | ||
|---|---|---|---|---|
| CAS Number | 1310540-32-9 | Molecular Weight | 734.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H36BrN7O9S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MPC-0767MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability[1]. |
| Name | MPC-0767 |
|---|
| Description | MPC-0767 is a potent, selective, and orally active hsp90 inhibitor. MPC-0767 is an L-alanine ester prodrug of MPC-3100 with improved chemical stability[1]. |
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| Related Catalog | |
| Target |
HSP90 |
| In Vivo | MPC-0767 (oral adminstration; 265 mg/kg; single dose) exhibits a improved PK property, the Tmax, Cmax, AUC and F% are 1 (h), 21562 ng/mL, 94194 h*ng/mL and 56%, respectively[1]. MPC-0767 (oral adminstration; 265 mg/kg) demonstrates comparable efficacy in an N-87 xenograft tumor model, the 46% tumor size reduction with no evidence of weight loss in the study animals[1]. MPC-0767 is well tolerated when administered at 252 mg/kg po (equivalent to 200 mg/kg dose of MPC-3100)[1]. |
| References |
| Molecular Formula | C26H36BrN7O9S2 |
|---|---|
| Molecular Weight | 734.64 |