1333327-56-2

1333327-56-2 structure

Name: TRC051384 HCl
Chemical Name: TRC051384
CAS Number: 1333327-56-2
Molecular Formula: C₂₅H₃₂ClN₅O₄
Molecular Weight: 502.01
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-06-05 10:36:07
Modify Date: 2024-02-25 20:38:36
TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke[1][2].

Name	TRC051384
Synonyms	MFCD31539844 1-[2-(4-Morpholinyl)ethyl]-3-(4-{(2E)-3-[6-(4-morpholinyl)-2-pyridinyl]-2-propenoyl}phenyl)urea hydrochloride (1:1) Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[(2E)-3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-, hydrochloride (1:1)

Description	TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Research Areas >> Neurological Disease
References	[1]. Mohanan A, et, al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9. [2]. Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244.