1359944-60-7

1359944-60-7 structure

Name: MRT-83 hydrochloride
Chemical Name: MRT-83 hydrochloride
CAS Number: 1359944-60-7
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2018-07-03 18:06:33
Modify Date: 2024-01-09 19:10:19
MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].

Name	MRT-83 hydrochloride

Description	MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	Smo[1]
In Vitro	MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].
References	[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.

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