Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation.[3] SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.


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Cyclopamine-KAAD

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist[1].

  • CAS Number: 306387-90-6
  • MF: C44H63N3O4
  • MW: 697.99
  • Catalog: Smo
  • Density: 1.15g/cm3
  • Boiling Point: 875.6ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 483.3ºC

AZD7254

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

  • CAS Number: 1126366-28-6
  • MF: C24H22N4O2
  • MW: 398.46
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LEQ506

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.

  • CAS Number: 1204975-42-7
  • MF: C25H32N6O
  • MW: 432.56100
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Fluticasone

Fluticasone is an inhaled corticosteroid used for respiratory diseases[1]. Fluticasone is a Smo agonist s with a IC50 value of 99 nM. Fluticasone activate Hedgehog signaling and promotes the proliferation of primary neuronal stem/precursor cells[2].

  • CAS Number: 90566-53-3
  • MF: C25H31F3O5S
  • MW: 500.571
  • Catalog: Glucocorticoid Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 568.3±50.0 °C at 760 mmHg
  • Melting Point: -18.1ºC
  • Flash Point: 297.5±30.1 °C

ALLO-2

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1].

  • CAS Number: 1357350-60-7
  • MF: C18H12F3N5O
  • MW: 371.32
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Jervine

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.IC50 value:Target: sonic hedgehog is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.

  • CAS Number: 469-59-0
  • MF: C27H39NO3
  • MW: 425.603
  • Catalog: Hedgehog
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 592.0±50.0 °C at 760 mmHg
  • Melting Point: 242- 244ºC
  • Flash Point: 311.8±30.1 °C

SMO-IN-3

SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

  • CAS Number: 2376914-71-3
  • MF: C27H25F4N3O2
  • MW: 499.50
  • Catalog: Hedgehog
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MRT-81

MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1].

  • CAS Number: 1263132-08-6
  • MF: C31H29N3O5S
  • MW: 555.64
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MK-4101

MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma.target:SMOIn vivo: MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice.In vitro: MK-4101 induce deregulation of cell cycle and block of DNA replication in tumors. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induce deregulation of cell cycle and block of DNA replication in tumors.

  • CAS Number: 935273-79-3
  • MF: C24H24F5N5O
  • MW: 493.472
  • Catalog: Smo
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 606.1±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 320.4±34.3 °C

SANT-1

SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].

  • CAS Number: 304909-07-7
  • MF: C23H27N5
  • MW: 373.49
  • Catalog: Hedgehog
  • Density: 1.13g/cm3
  • Boiling Point: 547.4ºC at 760mmHg
  • Melting Point: 104-106ºC
  • Flash Point: 284.8ºC

AZD8542

AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.

  • CAS Number: 1126366-36-6
  • MF: C25H24N4O2
  • MW: 412.48
  • Catalog: Hedgehog
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

PF-04449913

Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.

  • CAS Number: 1095173-27-5
  • MF: C21H22N6O
  • MW: 374.439
  • Catalog: Smo
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 633.4±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 336.9±31.5 °C

TPB15

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

  • CAS Number: 2170347-69-8
  • MF: C18H9Cl4N5O
  • MW: 453.11
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Halcinonide

Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.

  • CAS Number: 3093-35-4
  • MF: C24H32ClFO5
  • MW: 454.959
  • Catalog: Smo
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 564.3±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 295.1±30.1 °C

SMO-IN-2

SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].

  • CAS Number: 1822355-27-0
  • MF: C25H25F4N5O2
  • MW: 503.49
  • Catalog: Hedgehog
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SMO-IN-1

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC50 of 89 nM against sonic Hh protein (shh)[1].

  • CAS Number: 1126365-66-9
  • MF: C24H22N4O2
  • MW: 398.46
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MRT-10

MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer[1][2].

  • CAS Number: 330829-30-6
  • MF: C24H23N3O5S
  • MW: 465.52200
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BMS-833923

BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.IC50 Value: 6-35 nM [1]Target: SmoothenedSMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway.in vitro: In vitro, BMS-833923 inhibits the expression of downstream effectors in the HH pathway (GLI1 and PTCH1) in cell lines that express wild-type SMO and those which express activated mutant forms of SMO (IC50values of 6-35 nM). In FACS-based binding assays, BMS-833923 inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM [1]. in vivo: Pharmacodynamic studies show that BMS-833923 robustly inhibits HH pathway activity with along duration of action after a single oral dose in medulloblastoma and pancreatic carcinoma xenograft models. The pharmacodynamic effects of BMS-833923 observed in these models translate into tumor growth inhibition at well-tolerated doses [1].Clinical trial: Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923). Phase 2

  • CAS Number: 1059734-66-5
  • MF: C30H27N5O
  • MW: 473.568
  • Catalog: Smo
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MRT-83 hydrochloride

MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Purmorphamine

Purmorphamine is a smoothened receptor agonist with an EC50 of 1 μM.

  • CAS Number: 483367-10-8
  • MF: C31H32N6O2
  • MW: 520.625
  • Catalog: Autophagy
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 790.3±70.0 °C at 760 mmHg
  • Melting Point: 210-212ºC
  • Flash Point: 431.8±35.7 °C

20(S)-Hydroxycholesterol

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].

  • CAS Number: 516-72-3
  • MF: C27H46O2
  • MW: 402.65
  • Catalog: Smo
  • Density: 1.03g/cm3
  • Boiling Point: 512.3ºC at 760mmHg
  • Melting Point: 136-137ºC
  • Flash Point: 213.1ºC

Smoothened Agonist (SAG) HCl

SAG (hydrochloride) is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with a Kd of 59 nM.

  • CAS Number: 2095432-58-7
  • MF: C28H29Cl2N3OS
  • MW: 526.52
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MRT-83

MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range.

  • CAS Number: 1263131-92-5
  • MF: C31H30N4O5
  • MW: 538.594
  • Catalog: Smo
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SMANT hydrochloride

SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].

  • CAS Number: 1177600-74-6
  • MF: C16H24BrClN2O
  • MW: 375.73200
  • Catalog: Hedgehog
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LY2940680

Taladegib (LY2940680) is an antagonist of the smoothened receptor.

  • CAS Number: 1258861-20-9
  • MF: C26H24F4N6O
  • MW: 512.502
  • Catalog: Smo
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 703.5±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 379.3±32.9 °C

Smoothened Agonist, HCl

(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].

  • CAS Number: 364590-63-6
  • MF: C28H28ClN3OS
  • MW: 490.06
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

GSA-10

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

  • CAS Number: 300833-95-8
  • MF: C26H30N2O5
  • MW: 450.527
  • Catalog: Smo
  • Density: 1.240±0.06 g/cm3
  • Boiling Point: 620.2±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 328.9±31.5 °C

Saridegib

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

  • CAS Number: 1037210-93-7
  • MF: C29H48N2O3S
  • MW: 504.76800
  • Catalog: Smo
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IHR 1

A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.

  • CAS Number: 548779-60-8
  • MF: C20H12Cl4N2O2
  • MW: 454.134
  • Catalog: Smo
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 488.4±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 249.2±28.7 °C

LDE225 (NVP-LDE225,Erismodegib)

Erismodegib (LDE225) is a potent and selective Smoothened (Smo) antagonist with IC50s of 1.3 nM and 2.5 nM for mouse and human Smo, respectively.

  • CAS Number: 956697-53-3
  • MF: C26H26F3N3O3
  • MW: 485.498
  • Catalog: Smo
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 544.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 283.1±30.1 °C