1392809-08-3
1392809-08-3 structure
- Name: MRL-871
- Chemical Name: 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid
- CAS Number: 1392809-08-3
- Molecular Formula: C22H12ClF3N2O3
- Molecular Weight: 444.7904896
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2018-06-27 14:09:27
- Modify Date: 2024-01-31 08:12:27
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MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
| Name | 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid |
|---|
| Description | MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1]. |
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| Related Catalog | |
| In Vitro | MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1]. |
| References |
| Molecular Formula | C22H12ClF3N2O3 |
|---|---|
| Molecular Weight | 444.7904896 |