MRL-871

Modify Date: 2024-01-31 08:12:27

MRL-871 Structure
MRL-871 structure
 Common Name MRL-871
CAS Number 1392809-08-3 Molecular Weight 444.7904896
Density N/A Boiling Point N/A
Molecular Formula C22H12ClF3N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MRL-871


MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

 Names

Name 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

 MRL-871 Biological Activity

Description MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
Related Catalog
In Vitro MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1].
References

[1]. Meijer FA, et, al. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. J Med Chem. 2020 Jan 9;63(1):241-259.

 Chemical & Physical Properties

Molecular Formula C22H12ClF3N2O3
Molecular Weight 444.7904896
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Chemsrc provides MRL-871(CAS#:1392809-08-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MRL-871 are included as well.>> amp version: MRL-871

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