MRL-871

Modify Date: 2026-07-01 18:56:02

MRL-871 structure	Common Name	MRL-871
	CAS Number	1392809-08-3	Molecular Weight	444.7904896
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₂ClF₃N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MRL-871

MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

Name	4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

Description	MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Cancer
In Vitro	MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1].
References	[1]. Meijer FA, et, al. Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. J Med Chem. 2020 Jan 9;63(1):241-259.

Molecular Formula	C₂₂H₁₂ClF₃N₂O₃
Molecular Weight	444.7904896

Name: Inhibition of human GAL4-fused RORgammat LBD transfected in Escherichia coli BL21(DE3...
Source: ChEMBL
Target: Nuclear receptor ROR-gamma
External Id: CHEMBL5264151

Name: In-vivo binding affinity to RORgamma in Zebrafish embryos assessed as increase green ...
Source: ChEMBL
Target: Danio rerio
External Id: CHEMBL5531622

Name: Ratio of IC50 for allosteric inverse agonist activity at recombinant human N-terminal...
Source: ChEMBL
Target: Nuclear receptor ROR-gamma
External Id: CHEMBL4714694

Name: Intrinsic clearance in human liver microsomes at 3 uM measured up to 90 mins in prese...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4380053

Name: Ratio of IC50 for allosteric inverse agonist activity at recombinant human N-terminal...
Source: ChEMBL
Target: Nuclear receptor ROR-gamma
External Id: CHEMBL4714695

Name: Stability in human liver microsomes assessed as parent compound remaining at 5 uM mea...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4380054

Name: Stability of the compound in plasma (unknown origin) assessed as parent compound rema...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4380055

Name: Allosteric inhibition of N-terminal his6-tagged human recombinant RORgamma LBD (261 t...
Source: ChEMBL
Target: Nuclear receptor ROR-gamma
External Id: CHEMBL5531615

Name: Protein binding in plasma (unknown origin) at 5 uM measured after 6 hrs by LC-MS base...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4380056

Name: Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residue...
Source: ChEMBL
Target: Nuclear receptor ROR-gamma
External Id: CHEMBL4338900

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MRL-871
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Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.