1629138-41-5
1629138-41-5 structure
- Name: SRI-011381
- Chemical Name: 1629138-41-5
- CAS Number: 1629138-41-5
- Molecular Formula: C20H31N3O
- Molecular Weight: 329.48
- Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
- Create Date: 2018-07-17 01:58:42
- Modify Date: 2024-01-02 21:51:45
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SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
| Name | 1629138-41-5 |
|---|---|
| Synonyms | MFCD01475985 |
| Description | SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1]. |
| In Vivo | SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. |
| References |
| Molecular Formula | C20H31N3O |
|---|---|
| Molecular Weight | 329.48 |