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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea
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1629138-41-5

1629138-41-5 structure

1629138-41-5 structure

Name: SRI-011381
Chemical Name: 1629138-41-5
CAS Number: 1629138-41-5
Molecular Formula: C₂₀H₃₁N₃O
Molecular Weight: 329.48
Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
Create Date: 2018-07-17 01:58:42
Modify Date: 2026-07-14 11:02:25
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

Name	1629138-41-5
Synonyms	SRI-011381 HCL 1-benzyl-3-cyclohexyl-1-(piperidin-4-ylmethyl)urea SRI-011381 SRI011381 N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea Urea, N'-cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl) SRI-011381, 10 mM in DMSO N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea MFCD01475985 Transforming owth factor beta,SRI011381,inhibit,multiple,neuroprotective,NALP3,collagen-1,SRI-011381,SRI 011381,TGF-β,sclerosis,Inhibitor,α-SMA,TGF-beta/Smad SRI-011381 (C381)

Description	SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Neurological Disease
In Vitro	SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].
In Vivo	SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
References	[1]. Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. [2]. Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.

Molecular Formula	C₂₀H₃₁N₃O
Molecular Weight	329.48

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