SRI-011381
Modify Date: 2024-01-02 21:51:45
SRI-011381 structure
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Common Name | SRI-011381 | ||
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| CAS Number | 1629138-41-5 | Molecular Weight | 329.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H31N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRI-011381SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. |
| Name | 1629138-41-5 |
|---|---|
| Synonym | More Synonyms |
| Description | SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. |
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| Related Catalog | |
| In Vitro | SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1]. |
| In Vivo | SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. |
| References |
| Molecular Formula | C20H31N3O |
|---|---|
| Molecular Weight | 329.48 |
| MFCD01475985 |