409086-68-6

409086-68-6 structure

Name: YM-01(YM-1)
Chemical Name: PyridiniuM, 2-[[3-ethyl-5-(3-Methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]Methyl]-1-Methyl-, chloride (1:1)
CAS Number: 409086-68-6
Molecular Formula: C₂₀H₂₀ClN₃OS₂
Molecular Weight: 417.975
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-06-16 23:21:06
Modify Date: 2024-01-06 08:14:03
YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2].

Name	PyridiniuM, 2-[[3-ethyl-5-(3-Methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]Methyl]-1-Methyl-, chloride (1:1)
Synonyms	2-{(Z)-[(5E)-3-Ethyl-5-(3-methyl-1,3-benzothiazol-2(3H)-ylidene)-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridinium chloride Pyridinium, 2-[(Z)-[(5E)-3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-1-methyl-, chloride (1:1) YM-1

Description	YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
In Vitro	YM-1 促进 Nnos 成熟过程中依赖 Hsp70 的步骤，阻断部分与 ATP 的结合[1]。 YM-1 (0-200 μM) 激活 Hsp70 与未折叠底物的结合[1]。 YM-1 (0.001-1000 μM) 将 Hsp70 转化为紧密亲和构象，与 Hsp70 结合的 IC50 值为 8.2 μM[1]。 YM-1 (0，0.1，0.5 和 1 μM；24 小时) 促进 nNOS 泛素化[1]。 YM-1 (5 和 10 μM；24 和 48 小时) 诱导 HeLa 细胞死亡和 hTERT-RPE1 细胞生长停滞[2] YM-1 (10 μM；48 小时) 上调 p53 和 p21，下调 FoxM1 和 survivin 的蛋白水平[2]。 Western Blot Analysis[2] Cell Line: HeLa and hTERT-RPE1 cell lines Concentration: 10 μM Incubation Time: 48 hoursI Result: Increased the level of p53 and p21 and decreased the level of FoxM1 and survivin.
In Vivo	YM-1 (1 mM；口服，持续 7 天) 通过激活 Hsp70 挽救果蝇中的 polyQ 毒性[1]。 Animal Model: UAS-hAR52Q flies with polyQ AR-induced dihydrotestosterone (DHT) phenotype[1] Dosage: 1 mM Administration: Oral administration; 1 mM, for 7 days Result: Weakened the DHT-dependent eye degeneration phenotype and rescued DHT-dependent pupal toxicity of the polyQ AR.
References	[1]. Wang AM, et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2013 Feb;9(2):112-8. [2]. Khondoker Md Zulfiker Rahman, et al. Effect of an Inhibitor of HSP70, YM-1, on Hikeshi Knockout Cells. Thermal Medicine. 2017, 33(4):129-134.

Molecular Formula	C₂₀H₂₀ClN₃OS₂
Molecular Weight	417.975
Exact Mass	417.073639
Storage condition	2-8°C

RIDADR	NONH for all modes of transport

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

409086-68-6	1427450-47-2
71327-48-5	882256-55-5
1268521-75-0	71277-19-5
71277-23-1	64845-92-7
71277-21-9	71277-22-0
1483602-84-1	1495498-03-7
1956335-27-5	1487959-95-4
1425044-75-2	1464159-48-5
148589-36-0	1470199-42-8
854415-19-3	1477834-24-4