677773-91-0

677773-91-0 structure

Name: SM-324405
Chemical Name: SM 324405
CAS Number: 677773-91-0
Molecular Formula: C₁₉H₂₃N₅O₄
Molecular Weight: 385.42
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2018-07-04 23:53:16
Modify Date: 2024-01-31 16:27:13
SM-324405 is a TLR7 agonist, with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively[1].

Name	SM 324405
Synonyms	Methyl {3-[(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl]phenyl}acetate MFCD30182295 Benzeneacetic acid, 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-, methyl ester

Description	SM-324405 is a TLR7 agonist, with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
In Vitro	SM-324405 is a novel candidate for immunotherapy of allergic diseases[1].
In Vivo	SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically[1]. SM-324405 exhibits t1/2 of 2.6 min in human plasma[2].
References	[1]. Ayumu Kurimoto, et al. Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J Med Chem. 2010 Apr 8;53(7):2964-72. [2]. M Biffen, et al. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br J Pharmacol. 2012 May;166(2):573-86.