96192-35-7
96192-35-7 structure
- Name: Fructosyl-lysine dihydrochloride
- Chemical Name: ε-N-Deoxyfructosyllysine dihydrochloride
- CAS Number: 96192-35-7
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-06-11 03:17:30
- Modify Date: 2024-01-02 18:42:10
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Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1].
| Name | ε-N-Deoxyfructosyllysine dihydrochloride |
|---|
| Description | Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1]. |
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| Related Catalog | |
| Target |
IC50: precursor to glucosepane[2] |
| In Vitro | Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2]. Fructosyl-lysine dihydrochloride (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2]. Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2]. |
| In Vivo | Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1]. |
| References |
| No Any Chemical & Physical Properties |