1036207-61-0

1036207-61-0 structure

Name: Tetrapeptide-30
Chemical Name: Tetrapeptide-30
CAS Number: 1036207-61-0
Molecular Formula: C₂₂H₄₀N₆O₇
Molecular Weight: 500.596
Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
Create Date: 2018-12-31 21:35:53
Modify Date: 2024-01-03 23:54:39
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation[1].

Name	Tetrapeptide-30

Description	Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
In Vitro	Tetrapeptide-30 (0-10 μg/mL, 24 h) can effectively reduce UVB-induced gene expression of IL-6, TNF-α and POMC (proopiomelanocorticotropin), and also decreased IL-8 gene expression in a dose-dependent manner[1]. Tetrapeptide-30 (PKEK) is highly hydrophilic and has good skin penetration in microemulsion[2].
References	[1]. Alessandra Marini, et al. Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol. 2012 Feb;21(2):140-6. [2]. Reinhard H H Neubert, et al. Dermal peptide delivery using enhancer moleculs and colloidal carrier systems. Part II: Tetrapeptide PKEK. Eur J Pharm Biopharm. 2018 Mar;124:28-33.