Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NSC130813
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Purity: 95.0%
Stocking Period: 10 Day
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1082532-95-3

1082532-95-3 structure

1082532-95-3 structure

Name: NSC130813
Chemical Name: NERI02
CAS Number: 1082532-95-3
Molecular Formula: C₂₆H₃₀Cl₄N₄O₂
Molecular Weight: 572.354
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-06-11 12:18:52
Modify Date: 2024-01-05 22:10:12
HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].

Name	NERI02
Synonyms	4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]phenol trihydrochloride Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-, hydrochloride (1:3) MFCD27978378

Description	HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
In Vitro	HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1]. HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1]. HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1].
References	[1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044-3050.

Molecular Formula	C₂₆H₃₀Cl₄N₄O₂
Molecular Weight	572.354
Exact Mass	570.112305
Storage condition	?20°C

RIDADR	NONH for all modes of transport