1082532-95-3
1082532-95-3 structure
- Name: NSC130813
- Chemical Name: NERI02
- CAS Number: 1082532-95-3
- Molecular Formula: C26H30Cl4N4O2
- Molecular Weight: 572.354
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2018-06-11 12:18:52
- Modify Date: 2025-08-25 18:53:36
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HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].
| Name | NERI02 |
|---|---|
| Synonyms |
4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]phenol trihydrochloride
Phenol, 4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-, hydrochloride (1:3) MFCD27978378 |
| Description | HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1]. HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1]. HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1]. |
| References |
| Molecular Formula | C26H30Cl4N4O2 |
|---|---|
| Molecular Weight | 572.354 |
| Exact Mass | 570.112305 |
| Storage condition | ?20°C |
| RIDADR | NONH for all modes of transport |
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