1148118-92-6

1148118-92-6 structure

Name: Tripolin A
Chemical Name: Tripolin A
CAS Number: 1148118-92-6
Molecular Formula: C₁₅H₁₁NO₃
Molecular Weight: 253.25274
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2018-12-24 10:01:26
Modify Date: 2025-08-24 16:20:57
Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].

Name	Tripolin A

Description	Tripolin A ((E)-Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Research Areas >> Others
Target	IC50: 1.5 μM (Aurora A), 7 μM (Aurora A)[1].
In Vitro	Tripolin A induces mitotic spindle defects and spindle pole abnormalities[1].
References	[1]. Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.