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1314378-18-1

1314378-18-1 structure
1314378-18-1 structure
  • Name: Bis-PEG2-PFP ester
  • Chemical Name: Bis-PEG2-PFP ester
  • CAS Number: 1314378-18-1
  • Molecular Formula: C20H12F10O6
  • Molecular Weight: 538.289712
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-06-14 13:48:12
  • Modify Date: 2024-01-11 19:05:43
  • Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name Bis-PEG2-PFP ester
Synonyms BIS-PEG2-PFP ESTER
Description Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog
Target

Non-cleavable

PEGs

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula C20H12F10O6
Molecular Weight 538.289712
Hazard Codes Xi