In Vivo |
Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats[2]. Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2]. Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3]. Animal Model: Rats[2] Dosage: 2.5, 5, 10, 20, 40 μg/kg. Administration: Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h). Result: Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
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