419532-92-6
419532-92-6 structure
- Name: Phenylpyropene C
- Chemical Name: S14-95
- CAS Number: 419532-92-6
- Molecular Formula: C28H34O5
- Molecular Weight: 450.57
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-07-14 03:01:27
- Modify Date: 2025-09-02 18:01:12
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Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].
| Name | S14-95 |
|---|---|
| Synonyms | Phenylpyropene C |
| Description | Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
ACAT:16.0 μM (IC50) |
| In Vitro | Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC50 of 16.0 μM in a dose dependent fashion[1]. Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC50s of 5.4 μM to approximately 10.8 μM[2]. Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages[2]. Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes[2]. |
| References |
| Molecular Formula | C28H34O5 |
|---|---|
| Molecular Weight | 450.57 |
| Hazard Codes | Xi |
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