99217-64-8

99217-64-8 structure

Name: Kushenol B
Chemical Name: Kushenol B
CAS Number: 99217-64-8
Molecular Formula: C₃₀H₃₆O₆
Molecular Weight: 492.603
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2019-01-10 17:33:41
Modify Date: 2024-01-21 12:03:22
Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1].

Name	Kushenol B
Synonyms	4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)- (2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-6-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one

Description	Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities[1]. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	IC50: 31 µM (cAMP PDE)[1]
References	[1]. Han-Tian Fan, et al. The rational search for PDE10A inhibitors from Sophora flavescens roots using pharmacophore‑ and docking‑based virtual screening. Mol Med Rep