1254472-97-3
1254472-97-3 structure
- Name: PBI-4050 sodium salt
- Chemical Name: PBI-4050
- CAS Number: 1254472-97-3
- Molecular Formula: C13H17NaO2
- Molecular Weight: 228.263
- Catalog: Signaling Pathways GPCR/G Protein GPR40
- Create Date: 2018-09-10 01:11:01
- Modify Date: 2025-08-26 10:39:45
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PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84.
| Name | PBI-4050 |
|---|---|
| Synonyms |
Benzeneacetic acid, 3-pentyl-, sodium salt (1:1)
R05571KE07 Sodium (3-pentylphenyl)acetate |
| Description | PBI-4050 acts as an agonist for GPR40 and as an antagonist or inverse agonist for GPR84. |
|---|---|
| Related Catalog | |
| Target |
GPR40, GPR84[1] |
| In Vivo | PBI-4050, a synthetic analogue of a medium–chain length fatty acid, binds to FFA receptor 1 (FFAR1/GPR40) and GPR84. To determine the potential role of PBI-4050 on diabetic kidney disease, The accelerated model of type 2 diabetic nephropathy, eNOS-/- db/db mice are utilized. Mice are treated with either vehicle or PBI-4050 (100 mg/kg) by daily gavage from 8-20 weeks of age. eNOS-/- db/db mice are moderately hypertensive, and PBI-4050 has no effect on blood pressure. Furthermore, compared with vehicle-treated mice, which exhibit a decrease in glomerular filtration rate (GFR) from 8-20 weeks, PBI-4050 preserves GFR. Podocyte number per glomerulus section markedly decreases from 8-20 weeks of age in vehicle-treated mice, while PBI-4050 treatment significantly slows this loss[1]. |
| Animal Admin | Mice[1] Type 2 diabetes eNOS-/- db/db mice on the BKS background are used. Genotyping is performed by PCR. A subset of eNOS-/- db/db male mice (8 weeks old) are randomized to 2 groups. One group is treated with PBI-4050 (100 mg/kg/day, n=10) , and the other group receive vehicle (water, n=12). Both PBI-4050 and water are given via daily gavage from 8-20 weeks. Mice are euthanized at 20 weeks of age. The second set of eNOS-/- db/db male mice are divided into 4 groups (8 mice in each group): vehicle (water), PBI-4050 (100 mg/kg/day), Captopril (0.75 mg/mL in drinking water), and PBI-4050 plus captopril. The treatment is begun at 16 weeks and ended at 24 weeks. The third set of eNOS-/- db/db male mice is divided into 2 groups (8 mice in each group): vehicle (water) and PBI-4050 (100 mg/kg/day). The treatment begins at 16 weeks and lasts up to 30 weeks or until death[1]. |
| References |
| Molecular Formula | C13H17NaO2 |
|---|---|
| Molecular Weight | 228.263 |
| Exact Mass | 228.112625 |