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  • DC Chemicals Limited
  • China
  • Product Name: GW-766994
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

408303-43-5

408303-43-5 structure
408303-43-5 structure
  • Name: GW 766994
  • Chemical Name: GW-766994
  • CAS Number: 408303-43-5
  • Molecular Formula: C21H24Cl2N4O3
  • Molecular Weight: 451.346
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-08-23 09:52:44
  • Modify Date: 2024-01-06 10:47:49
  • GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

Name GW-766994
Synonyms 4-{[({[(2S)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
Z6213K1TPE
Benzamide, 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-
GW-766994
Description GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.
Related Catalog
Target

CCR3:7.86 (pKi)

In Vitro GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].
References

[1]. Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16.

[2]. Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978.

Density 1.3±0.1 g/cm3
Boiling Point 685.8±55.0 °C at 760 mmHg
Molecular Formula C21H24Cl2N4O3
Molecular Weight 451.346
Flash Point 368.5±31.5 °C
Exact Mass 450.122559
LogP 1.50
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.608
Storage condition 2-8℃