500794-88-7
500794-88-7 structure
- Name: TR antagonist 1
- Chemical Name: TR antagonist 1
- CAS Number: 500794-88-7
- Molecular Formula: C25H23Br2NO4
- Molecular Weight: 561.26
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-08-17 22:19:40
- Modify Date: 2024-01-14 07:39:14
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TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
| Name | TR antagonist 1 |
|---|
| Description | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. |
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| Related Catalog | |
| Target |
IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α)[1] |
| In Vitro | TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC50=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC50 32 nM for both TRAFα1 and TRAFβ1[1]. |
| In Vivo | TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1]. |
| References |
| Molecular Formula | C25H23Br2NO4 |
|---|---|
| Molecular Weight | 561.26 |