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Product Name: EPAC 5376753
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302826-61-5

302826-61-5 structure

302826-61-5 structure

Name: EPAC 5376753
Chemical Name: EPAC 5376753
CAS Number: 302826-61-5
Molecular Formula: C₁₅H₈Cl₂N₂O₃S
Molecular Weight: 367.21
Catalog: Research Areas Cancer
Create Date: 2018-08-14 13:25:05
Modify Date: 2025-08-21 06:16:36
EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.

Name	EPAC 5376753

Description	EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease
Target	IC50: 4 µM (Epac)[1]
In Vitro	Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts[1].
Cell Assay	Swiss 3T3 cells are treated with EPAC 5376753 (1, 10, 25, 50, 75, 100 μM) or 1% dimethyl sulfoxide for 48 h. Cell viability is assessed using the CellTiter-Glo assay[1].
References	[1]. Brown LM, et al. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. J Biol Chem. 2014 Oct 17;289(42):29148-57.

Molecular Formula	C₁₅H₈Cl₂N₂O₃S
Molecular Weight	367.21

Hazard Codes	Xi

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