303126-97-8
303126-97-8 structure
- Name: SR 0987
- Chemical Name: SR0987
- CAS Number: 303126-97-8
- Molecular Formula: C16H10ClF6NO2
- Molecular Weight: 397.699
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2019-01-20 16:45:39
- Modify Date: 2024-02-11 22:31:42
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SR0987 is a RORγt agonist, with an EC50 of 800 nM.
| Name | SR0987 |
|---|---|
| Synonyms |
2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl]benzamide
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- MFCD02693203 |
| Description | SR0987 is a RORγt agonist, with an EC50 of 800 nM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 800 nM (RORγt)[1]. |
| In Vitro | SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 378.8±42.0 °C at 760 mmHg |
| Molecular Formula | C16H10ClF6NO2 |
| Molecular Weight | 397.699 |
| Flash Point | 182.9±27.9 °C |
| Exact Mass | 397.030426 |
| LogP | 4.36 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.541 |
| Storage condition | 2-8℃ |