638213-98-6

638213-98-6 structure

Name	AGL-2263
Synonyms	(2E)-2-(3,4-Dihydroxybenzoyl)-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acrylonitrile

Description	AGL-2263 is an insulin receptor (IR) blocker.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor Research Areas >> Metabolic Disease
Target	Insulin receptor[1].
In Vitro	AGL-2263 is an insulin receptor (IR) blocker[1].
Cell Assay	Trophoblast cells are prepared from normal or GDM placentas. They are incubated in the presence of stimulants, insulin (100 nM) or both insulin and AGL-2263 (AGL, 5 μM) IR blocker, together for 24 hr[1].
References	[1]. Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705.