1334850-99-5
1334850-99-5 structure
- Name: Mito-TEMPO
- Chemical Name: Mito-TEMPO
- CAS Number: 1334850-99-5
- Molecular Formula: C29H35ClN2O2P
- Molecular Weight: 510.03
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Mitochondrial Metabolism
- Create Date: 2019-01-20 14:48:57
- Modify Date: 2024-01-02 16:47:21
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Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties.
| Name | Mito-TEMPO |
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| Description | Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties. |
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| Related Catalog | |
| In Vivo | Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3[1]. |
| Animal Admin | Mice[1] Male C57BL/6J mice (8-12 weeks) and RIP3-deficient mice (C57BL/6N background) are used throughout the study. The mice are acclimated before experiments with free access to diet and water. Overnight-fasted mice (16-18 h) are treated i.p. with 300 mg/kg APAP dissolved in warm saline. Some mice are treated with 200 mg/kg APAP in experiments evaluating effect of RIP3 deficiency. A dose of 20 mg/kg Mito-Tempo dissolved in saline is administered i.p. 1.5 or 3 h after APAP. Some mice are subsequently treated (i.p.) with 10 mg/kg ZVD fmk dissolved in Tris-buffered saline or vehicle 2 h after APAP. To mimic the clinical care of APAP-overdose patients, some mice receive the antidote NAC (i.p., 500 mg/kg) at 1.5 or 3 h after APAP overdose[1]. |
| References |
| Molecular Formula | C29H35ClN2O2P |
|---|---|
| Molecular Weight | 510.03 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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